Pharmacokinetic Study of 2 Doses of ATV/r OD + 2 NRTIs in Thai HIV-1 Infected Patients
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
Several studies from HIV-NAT have demonstrated high nevirapine, indinavir, saquinavir and
lopinavir/r levels when compared to Caucasian patients. Until now, the pharmacokinetics of
atazanavir have not been explored in a Thai population. We postulate that ATV levels, as with
other PIs, are higher in Thai people. Therefore, the level of ATV in ATV/RTV 300/100 OD may
be higher than the acceptable range and could be associated with ATV related toxicity.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
The HIV Netherlands Australia Thailand Research Collaboration