Pharmacokinetic Study of Primaquine and Chloroquine in Healthy Subjects
Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
This is a standard pharmacokinetic interaction study. Subjects will be randomized to be
either group A or B. Group A. Subjects will have 3 hospitalizations to complete. Each
hospitalization will be about 12-24 hours depends on each regimen. Subjects in A group who
receive regimen 1 of primaquine (PQ) on the first admission (visit 2) will receive regimen 2
of primaquine and chloroquine combination (PQ and CQ) on second admission (visit 3) after 1
week wash out period and will finish with regimen 3 of Chloroquine (CQ) on the third
admission (visit 4) after 8 weeks wash out period.
Subjects in B group who receive regimen 1 of primaquine (PQ) will receive regimen 2 of
chloroquine (CQ) on second admission (visit 3) after 1 week wash out period and regimen 3 of
primaquine and chloroquine combination (PQ and CQ)on third admission(visit 4) with 8 week
wash out period in between.