Pharmacokinetic of Ceftriaxone in Septic ICU Patients

• Status: Unknown status
• Trial end date: 2007-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Ceftriaxone pharmacokinetics variability in intensive care unit septic patients

In intensive care units, drug dosage is often based on study made on healthy volunteers or on less severe patients.

However, pharmacokinetic alterations have been described for some drugs used in intensive care units.

These alterations, consequences of alteration of volume of distribution, of protein concentrations, of impaired hepatic and renal functions can result in accumulation with toxicity or " under dosage " with inefficacity.

Ceftriaxone is an antibiotic often prescribed in intensive care unit. However, despite this large utilisation, very few data is available on the pharmacokinetic in intensive care unit, and optimal dosage is not known.

Our objective is to develop a population pharmacokinetics model of ceftriaxone in intensive care unit patients with sepsis, severe sepsis and septic shock and to identify the " data " explaining interindividual variability of each pharmacokinetics parameter.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Association Pour La Promotion A Tours De La Reanimation Medicale
• Treatments: Ceftriaxone

Criteria

Inclusion Criteria:

• Eighteen-year or more

• sepsis, severe sepsis or septic shock (according to Bone's criteria)

• admission to intensive care unit

• informed consent obtained

• affiliation to medicare

Exclusion Criteria:

• Previous haemodialysis

• hemopathy

• known allergy to cephalosporin

• patients whose death is considered imminent