Pharmacokinetics, -Dynamics and Safety of Intravenous Paracetamol in Neonates
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is triple, i.e. document single dose pharmacokinetics and -dynamics
of intravenous paracetamol in preterm and term neonates after a loading dose (20 mg/kg iv
bolus paracetamol), document multiple dose pharmacokinetics and -dynamics of intravenous
paracetamol in preterm and term neonates, based on the daily doses routinely used within the
neonatal intensive care unit and as reported in literature. Finally, document safety of
single and repeated dose of intravenous paracetamol in preterm and term neonates.