Pharmacokinetics and Pharmacodynamics of Intravenous Artesunate for Severe Malaria Treatment

• Status: Unknown status
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Intravenous artesunate is highly effective with rapid schizonticidal action and improved clinical outcome

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Makerere University
• Treatments: Artemisinins; Artesunate

Criteria

Inclusion Criteria:

1. Patients aged 18 years and above

2. With severe malaria according to the following ciriteria:

3. A positive blood smear for malaria with P. falciparum mono-infection with parasitemia > 500 parasites/ul of blood

4. Who according to the attending physician require parenteral treatment and admission for malaria

5. Willing to participate in the study

6. Who are or whose first degree parents/caretakers are able to provide written informed consent

Exclusion Criteria:

1. Patients with history of prior antimalarial use within the last 72 hours

2. Pregnant women

3. Patients with contraindications to taking the study drugs

4. Patients taking known inhibitors or inducers of cytochrome P450 -