Pharmacokinetics and Pharmacodynamics of Ivermectin in Pediatric Dengue Patients
Status:
Completed
Trial end date:
2020-09-22
Target enrollment:
Participant gender:
Summary
Design and Outcomes This research study is designed as open-label, sequential dose-escalating
clinical trial. There will be two phases of enrollment.
In the first phase, pediatric dengue patients with body weight greater than 30 kg will be
recruited. The first six volunteers will be administered with 400 μg/kg every 24 hours for a
total of three times. The last six volunteers will be administered with 600 μg/kg every 24
hours for a total of three times.
In the second phase, pediatric dengue patients with body weight between 15 to 30 kg will be
recruited. Similar to the first phase, the first six and the last six volunteers will be
administered with 400 μg/kg and 600 μg/kg every 24 hours for a total of three times,
respectively.
A total of 24 volunteers will be recruited from Faculty of Medicine Siriraj hospitals