Pharmacokinetics and Point of Care Testing of Direct Oral Anticoagulants Subjects
Status:
Active, not recruiting
Trial end date:
2023-12-30
Target enrollment:
Participant gender:
Summary
DOACs are increasingly used since 8 years. Standard coagulation tests (Prothrombin time [PT]
and activated partial thromboplastin time [aPTT]) from plasma samples show a high variation.
Special coagulation tests like hemoclot for dabigatran and chromogenic substrate assays for
Rivaroxaban, Apixaban, and Edoxaban are time-consuming and can be performed only in
specialized laboratories. In specific medical situations like in patients such as emergency
procedures, stroke (before starting thrombolytic therapy), trauma, general surgery or other
invasive procedures, it may be necessary for medical decision making to know the presence or
absence of a DOAC in patient's body fluid. Until now there is no rapid, specific and
sensitive coagulation test available in the market.