Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure

• Status: Completed
• Trial end date: 2014-10-21
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to conduct a population pharmacokinetic analysis of caspofungin in a population of patients with moderate and severe acute alcoholic hepatitis or liver disease with Child-Pugh score B and C in order to better characterize pharmacokinetic parameters in case of moderate and severe liver dysfunction.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Erasme University Hospital
• Treatments: Caspofungin; Echinocandins

Criteria

Inclusion Criteria:

• Liver failure Child-Pugh B and C

Exclusion Criteria:

• Cachexia (BMI < 15 kg/m²)

• Pregnancy

• HIV

• Hepatitis C patients