Pharmacokinetics of Different Mode Administration of Intranasal Dexmedetomidine
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Intranasal dexmedetomidine has been studied and used in children for premedication before
anaesthesia or fro sedation. It can be administered by simple dripping or by Mucosal
Atomization Device (MAD®).
Since MAD® delivers intranasal medication in a fine mist, it is possible that absorption and
bioavailability would be better compares to simple dripping method. To date no
pharmacokinetic information of intranasal dexmedetomidine delivered by either method is
available. This investigation is designed to compare the bioavailablity of intranasal
dexmedetomidine deliver via simple dipping with tuberculine syringe and MAD® in healthy
adults.