Overview

Pharmacokinetics of Fluconazole IV as Prophylaxis or Therapy to ICU Patients

Status:
Completed

Trial end date:
2016-03-01

Target enrollment:
0

Participant gender:
All

Summary

The pharmacokinetics of fluconazole are expected to be different in ICU patients compared to non-ICU patients. The investigators will determine fluconazole and free fluconazole concentrations in 20 ICU patients, who will get intravenous fluconazole as standard care. Switching to oral/enteral fluconazol is allowed after day 3. A full pharmacokinetic curve will be taken on day 3 of iv therapy and limited pharmacokinetic curves on day 7 of iv therapy and/or on day 3 of oral therapy; trough levels will be taken daily after intravenous therapy.

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Radboud University

Treatments:

Fluconazole

Criteria

Inclusion Criteria:

1. Patient is admitted to an ICU

2. Subject is at least 18 years of age on the day of the first dosing

3. Subject is managed with a central venous or arterial catheter

Exclusion Criteria:

1. Is known to be hypersensitive to azole antifungal agents

2. Documented history of sensitivity to medicinal products or excipients similar to those
found in the fluconazole preparation

3. Has previously participated in this trial