Pharmacokinetics of Intranasal Ketorolac in Children

• Status: Terminated
• Trial end date: 2017-11-29
• Target enrollment: 0
• Participant gender: All

Summary

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) that is typically given to both adults and children by the intravenous (IV) or intramuscular (IM) route for analgesic purposes. Ketorolac can also be given by the intranasal (IN) route using a mucosal atomization device (MAD). We aim to study the pharmacokinetics of ketorolac when administered by the IN route using the MAD.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Columbia University
• Treatments: Ketorolac; Ketorolac Tromethamine

Criteria

Inclusion Criteria:

• Present to the emergency department with a painful condition for which the treating physician decides to administer ketorolac as part of their usual care.

Exclusion Criteria:

• Known allergy to ketorolac

• Contraindication to receiving ketorolac

• Receiving any NSAID within the past 6 hours

• Presence of an intranasal obstruction that cannot be readily cleared using suction or nose-blowing

• Inability to speak English or Spanish

• Critical illness