Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors
Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether oral intake of COMT inhibitors affects the
smooth plasma levodopa levels achieved by intestinal levodopa/carbidopa infusion in advanced
Parkinson's disease patients. The hypothesis is that COMT inhibitors make plasma
concentrations of levodopa more fluctuating.
Phase:
Phase 4
Details
Lead Sponsor:
Uppsala University
Collaborators:
Swedish Parkinson's Disease Foundation Swedish Society for Medical Research