Pharmacokinetics of Preoperative Vancomycin

• Status: Completed
• Trial end date: 2015-07-20
• Target enrollment: 0
• Participant gender: All

Summary

A study of plasma and tissue vancomycin pharmacokinetics in pediatric surgical patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Treatments: Vancomycin

Criteria

Inclusion Criteria:

1. Neurosurgery patients between the ages of 31 days up to 18 years

2. Receiving a single dose of vancomycin administered prior to surgery for cerebrospinal fluid (CSF) shunt placement or revision.

3. Orthopedic surgical patients between the ages of 31 days up to 18 years

4. Receiving a single dose of vancomycin administered prior to surgery for definitive spinal fusion.

Exclusion Criteria:

1. Patients already receiving vancomycin for treatment of an active infection,

2. Patients who have a Creatinine ≥1.2,

3. Patients who's creatinine clearance less than 50,

4. Known chronic renal failure and are on dialysis,

5. Patients with a known allergy to vancomycin, not including Red Man Syndrome.