Pharmacokinetics of Sugammadex (MK-8616) in Participants With Moderate and Severe Renal Insufficiency (MK-8616-105)
Status:
Completed
Trial end date:
2014-06-06
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the plasma pharmacokinetics of a single 4 mg/kg
intravenous (IV) dose of sugammadex in participants with moderate and severe renal
insufficiency compared to that in participants with normal renal function. The study consists
of two parts. In Part 1, participants with renal insufficiency and healthy participants will
be administered study drug by IV bolus injection into a peripheral vein. In Part 2,
participants with renal insufficiency and healthy participants will be administered study
drug as an IV bolus into a peripheral vein, through an IV catheter connected to IV tubing
with injection port. Subjects who participate in Part 1 of study may be enrolled in Part 2,
which would reduce the overall number of participants enrolled for the study.