Pharmacokinetics of Thiamine in Breastfeeding Mothers and Infants
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
Thiamine deficiency causes beriberi and is common in parts of rural Cambodia, where it
appears to be a leading cause of infant death. The change in maternal and infant thiamine
level after administration of thiamine to either Cambodian mothers or their infants is
unknown. Normal human breast milk thiamine levels in thiamine-replete mothers are poorly
characterized. The aim of this study is to determine if thiamine administered to nursing
Cambodian mothers normalizes maternal and infant thiamine levels. Levels will also be
obtained in nursing Caucasian mothers residing in the United States.