Pharmacologic MRI in Cocaine Addiction

• Status: Completed
• Trial end date: 2016-08-01
• Target enrollment: 0
• Participant gender: All

Summary

In the proposed study, the investigators will assess the brain response to medication probes the investigators have previously studied with SPECT. The brain response to ondansetron and lidocaine infusions will be measured Arterial Spin Labeling and functional connectivity MRI (fcMRI).

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Treatments: Cocaine; Lidocaine; Ondansetron

Criteria

Inclusion Criteria:

• Cocaine dependence (cocaine patients)

• identify cocaine as their present primary drug of use

• Patients must have used cocaine within the previous 4 weeks (by patient history) and be abstinent for at least 1 week.

• No drug dependence (healthy control population).

Exclusion Criteria:

• Other medical or psychiatric disorders that may effect neural functioning.

• Medications that may effect brain functioning