Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity

• Status: Completed
• Trial end date: 2008-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study on pharmacological intervention in autonomic nervous dysregulation(parasympathetic dysfunction,) regarding insulin resistance, is a concept testing in humans tohelp identify potential new pharmacological target sites in the central nervous system.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: AstraZeneca
• Treatments: Atropine; Physostigmine

Criteria

Inclusion Criteria:

• Signed written informed consent

• BMI of lean and abdominally obese men and women

• weight stable

Exclusion Criteria:

• Ongoing clinically significant diseases

• History of repeated syncope

• resting pulse<50 or systolic blood pressure <100