Pharmacological Study of High Doses of Ceftriaxone in Meningitidis

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to describe the concentrations of Ceftriaxone at the steady state, in patients treated for meningitis, to determine pharmacokinetic parameters at high dose in this population. Additionally, we aimed to detect adverse effect, especially neurological trouble related to Ceftriaxone toxicity.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nantes University Hospital
• Treatments: Ceftriaxone

Criteria

Inclusion Criteria:

• Hospitalized adults patients,

• age equal or above 18

• Patients with Community or surgical acquired neurological infections, meningitis and others

• Prescription of ceftriaxone >75mg/kg/d or >4g/d -

• Subjects affiliated to French health insurance (social security)

• Informed consent form signed

Exclusion Criteria:

• Patient under guardianship