Pharmacological Treatment In Osteoarthritis

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the efficacy of hydroxychloroquine in hand osteoarthritis.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Maasstad Hospital
• Treatments: Hydroxychloroquine

Criteria

Inclusion Criteria:

• Age ≥ 40 years

• Primary hand OA according to the ACR classification

• Heberden or Bouchard nodule or Kellgren-Lawrence grade 1, 2 or 3 changes in ≥ 2 symptomatic joints

• Pain in the dominant hand ≥ 12 months

• Use of an NSAID for ≥ 1 episode of pain

• Written informed consent

Exclusion Criteria:

• Secondary hand OA, e.g. haemochromatoses, rheumatoid arthritis, posttraumatic

• Kellgren-Lawrence grade 4 OA

• Use of hydroxychloroquine within 3 months before entering the study

• Use of NSAIDs or corticosteroids within 7 days before entering the study

• Retinopathy

• Myasthenia gravis

• Known allergy or hypersensitivity for hydroxychloroquine