Pharmacology of Antimalarial Therapy With or Without Antiretroviral Therapy
Status:
Terminated
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to see if taking nevirapine (NVP) for HIV changes the way
artemether/lumefantrine (AL) works in children who are co-infected with both HIV and malaria.
The brand of AL used in this study is Coartem® Dispersible. This study will compare the blood
levels of AL in co-infected children who already take NVP prescribed by their doctor with the
co-infected children who do not take anti HIV medicines because they do not meet national
guidelines to start them. The study will also assess the safety of using both medications (AL
and NVP) in children.
Phase:
Phase 4
Details
Lead Sponsor:
International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Collaborators:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Antimalarials Artemether Artemether-lumefantrine combination Artemether, Lumefantrine Drug Combination Artemisinins Lumefantrine