Phase 1 Dose Escalating Study to Assess Safety, Tolerability, Food Effect and PK of CHR-5154 in Healthy Male Volunteers
Status:
Terminated
Trial end date:
2014-05-28
Target enrollment:
Participant gender:
Summary
Primary Objective:
• To determine the safety and tolerability of single and multiple ascending oral doses of
CHR-5154 in healthy volunteers.
Secondary Objectives:
- To determine the pharmacokinetic profile of CHR-5154 and its metabolite CHR-5426.
- To compare the pharmacokinetic profile of CHR-5154 and CHR-5426 after a single dose of
CHR-5154 in the fed and fasted state.