Overview

Phase 1 Trial To Evaluate mFOLFOX6 With Selinexor In Patients With Metastatic Colorectal Cancer

Status:
Completed
Trial end date:
2017-03-09
Target enrollment:
Participant gender:
Summary
This trial will evaluate the combination treatment of established chemotherapy regimen mFOLFOX6 with Selinexor, an oral Selective Inhibitor Of Nuclear Export, in patients with metastatic Colorectal Cancer. The purpose is to determine the maximum tolerated dose (MTD) of selinexor in combination with mFOLFOX6.
Phase:
Phase 1
Details
Lead Sponsor:
GSO Global Clinical Research BV
Collaborators:
Karyopharm Therapeutics Inc
Karyopharm Therapeutics, Inc
Treatments:
Folic Acid
Leucovorin
Levoleucovorin
Oxaliplatin