Phase 1b Study Investigating the Association of NP137 With Atezolizumab-Bevacizumab Combination in First Line in Unresectable Hepatocellular Carcinoma

• Status: Not yet recruiting
• Trial end date: 2024-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The study will assess the safety of the association of NP137 with the standard of care Atezolizumab-Bevacizumab in first line setting in patients with unresectable hepatocellular carcinoma.The study drug which is tested is the NP137 in association with Atezolizumab-Bevacizumab to allow a better tumor response as well as better survival outcomes with an acceptable safety.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Grenoble
• Collaborator: NETRIS Pharma
• Treatments: Atezolizumab; Bevacizumab

Criteria

Inclusion Criteria:

1. Males or females ≥ 18 years of age

2. Histologically confirmed (liver biopsy within 24 previous weeks) and documented unresectable hepatocellular carcinoma

3. No prior systemic therapy for advanced HCC.

4. Liver tumor burden < 50% of the liver (per Investigator judgment)

5. Child-Pugh A (≤ 6) without any history of cirrhotic decompensation within the past 6 months

6. Antiviral therapy required in hepatitis B virus patients (Hepatitis B antigen positive)

7. Willing to have liver biopsy between C4 and C5

8. Presence of a measurable tumor per RECIST v1.1 criteria

9. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1

10. Life expectancy ≥ 12 weeks

11. Absence of previous liver decompensation

12. In case of cirrhosis, last esophageal varices detection by esogastroduodenal endoscopy have to be performed within last the 6 months before inclusion

13. Adequate hematologic function prior to the first dose of NP137, defined as:

1. Absolute neutrophils count ≥ 1500 cells/µL

2. Hemoglobin ≥ 9 g/dL with no transfusion within 4 weeks prior to first planned dose of NP137

3. Platelet count > 50,000/µL with no transfusion within 2 weeks prior to first planned dose of NP137

14. Adequate renal function prior to first dose, defined as

1. Serum creatinine < 1.5 ULN

2. Creatinine clearance ≥ 30 mL/min/m2 (by Cockroft-Gault equation of 24-hour urine) if creatinine ≥ 1.5 X ULN

15. Adequate hepatic function prior first dose, defined as AST/ALT ≤ 5 X ULN

16. Women patients of childbearing potential* must have a negative serum pregnancy test at screening and baseline, and be willing to use a highly effective** contraception. The patient should be advised to continue the contraception for at least 6 months following the completion of dosing. Women with cessation for > 24 months of previously occurring menses, or women of any age who have had a hysterectomy, or have had both ovaries removed will be considered to be of non-childbearing potential.

17. Male patients of reproductive potential must be willing to use one acceptable method of contraception, as judged by Investigator and Sponsor and/or to refrain from donating sperm from the time of screening through at least 6 months following the completion of dose administration.

18. Amenable to computed tomography (CT) with 3 or 4 phase liver or magnetic resonance imaging (MRI) of abdomen and pelvis, and CT of chest, or MRI of whole body, for initial tumor size measurements and subsequent follow-up.

19. Absence of other clinically relevant abnormalities for any screening laboratory test results as judged by the Investigator and Sponsor.

20. Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.

21. Able to understand and provide written informed consent

22. Patients covered by Health Insurance System

Exclusion Criteria:

1. Any known history of encephalopathy

2. Untreated or incompletely treated esophageal and/or gastric varices with bleeding or high-risk for bleeding

3. Known esophageal varices with recent history of bleeding (within previous 6 months)

4. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures

5. Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC

6. Chronic treatment with immunosuppressive agents (like steroids) ≤ 6 weeks prior to first planned dose of treatment.

7. Major surgical procedures, open biopsy or significant traumatic injury ≤ 4 weeks prior to first dose of treatment or anticipation of major surgical procedure during the course of the trial, minor surgical procedures ≤ 1 week of first planned dose

8. Local therapy to liver within 28 days prior to initiation of study treatment or non-recovery from side effects of any such procedure

9. Any clinically significant cardiovascular condition as judged by the Investigator

10. Severe or uncontrolled renal condition

11. Untreated chronic hepatitis B

12. Co-infection of HBV and HCV

13. Use of any prohibited concomitant medications within 14 days of the Baseline/Day 1 visit

14. Contraindication to additionnal liver biopsy planned between C4 and C5

15. Contraindication to iodinated contrast agent infusion

16. Known current alcohol (> 20g/ Day in women and > 30g/ Day in men) or substance abuse

17. History of leptomeningeal disease

18. Active or history of autoimmune disease or immune deficiency

19. History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography scan

20. Known active tuberculosis

21. History of malignancy other than HCC within 5 years prior to screening, with the exception of malignancies with a negligible risk of metastasis or death

22. Pregnancy or breastfeeding, or intention of becoming pregnant during study treatment or within at least 6 months after the last dose of treatment

23. Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases

24. Uncontrolled tumor-related pain

25. Uncontrolled or symptomatic hypercalcemia

26. Treatment with systemic immunostimulatory agents

27. Inadequately controlled arterial hypertension

28. Prior history of hypertensive crisis or hypertensive encephalopathy

29. Evidence of bleeding diathesis or significant coagulopathy

30. History of intestinal obstruction and/or clinical signs or symptoms of GI obstruction including sub-occlusive disease related to the underlying disease or requirement for routine parenteral hydration

31. Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture

32. Metastatic disease that involves major airways or blood vessels, or centrally located mediastinal tumor masses

33. Known clinically significant or life threatening organ or systemic disease such that in the opinion of the Investigator, the significance of the disease will compromise the patient's participation in the trial

34. Known intolerance or hypersensitivity to the active ingredient or to one of the components of the study drug

35. Subject in exclusion period for another study,

36. Subject who cannot be contacted in an emergency

37. Persons referred to in Articles L1121-5 to L1121-8 of the French code of public health (this corresponds to all persons protected: pregnant or parturient women, breastfeeding mothers, persons deprived of liberty by judicial or administrative decision, persons subject to a legal protection measure).