Phase 2 Neoadjuvant Doxorubicin and Cyclophosphamide -> Docetaxel With Lapatinib in Stage II/III Her2Neu+ Breast Cancer
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
This trial combines dose dense chemotherapy with doxorubicin and cyclophosphamide (AC)
followed by standard, every 3 week docetaxel and GW572016 (lapatinib) for neoadjuvant
treatment of Her2neu positive stage II/III breast cancer. The purpose of the study was to
determine whether lapatinib combined with chemotherapy was safe and resulted in an increase
in pathologic complete response rates.