Phase 2 Study of GSK1363089 (Formerly XL880) in Adults With Squamous Cell Cancer of the Head and Neck
Status:
Completed
Trial end date:
2009-05-02
Target enrollment:
Participant gender:
Summary
This study is being conducted to determine the best confirmed response rate, safety, and
tolerability of GSK1363089 treatment in adult subjects with squamous cell carcinoma of the
head and neck (SCCHN). GSK1363089 is a new chemical entity that inhibits multiple receptor
tyrosine kinases (RTKs) with growth-promoting and angiogenic properties. The primary targets
of GSK1363089 are the HGF and vascular endothelial growth factor (VEGF) RTK families (eg,
MET, VEGFR2/kinase insert domain receptor [KDR]). Since MET overexpression has been
associated with poorer prognosis and MET tyrosine kinase mutations have been reported in
SCCHN, inhibition of MET receptor and VEGFR2/KDR activation by agents such as GSK1363089 may
be of therapeutic benefit in this patient population.