Phase I/II Study of High-Dose Calcitriol Plus Temodar for Patients With Metastatic Melanoma
Status:
Completed
Trial end date:
2012-07-09
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Calcitriol may help temozolomide kill more tumor cells by making them more sensitive to the
drug. Calcitriol may also stop the growth of melanoma by blocking blood flow to the tumor.
PURPOSE: This phase I/II trial is studying the best dose of calcitriol, the side effects of
calcitriol when given together with temozolomide, and to see how well they work in treating
patients with metastatic stage IV melanoma.