Overview

Phase I/II Study to Evaluate the Efficacy and Safety of a Combination Chemotherapy

Status:
Terminated
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
A pilot trial of combination of bortezomib, bevacizumab and carboplatin as first line therapy in patients with metastatic Non-Small Cell Lung Cancer (NSCLC). Phase I and II study of this combination in first line setting will be conducted in order to properly estimate the efficacy and safety of this regimen. This will form the basis for future studies comparing this combination to what is now considered standard regimen for first line therapy in patients with NSCLC, carboplatin, paclitaxel and bevacizumab.
Phase:
Phase 1
Details
Lead Sponsor:
University of Massachusetts, Worcester
Collaborators:
Genentech, Inc.
Millennium Pharmaceuticals, Inc.
Treatments:
Bevacizumab
Bortezomib
Carboplatin
Docetaxel