Overview

Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

Status:
NOT_YET_RECRUITING

Trial end date:
2031-12-01

Target enrollment:

Participant gender:

Summary

The purpose of the Phase I study is to see if it is safe to use X-ray photon radiation (XRT) and proton radiation (PT) before surgery in patients with recurrent head and neck squamous cell carcinoma (rHNSCC). The purpose of the Phase II study is to see if using XRT or PT before immunotherapy (pembrolizumab) prior to surgery benefits patients with recurrent head and neck squamous cell carcinoma (rHNSCC).

Phase:

PHASE1

Details

Lead Sponsor:

University of Cincinnati

Treatments:

pembrolizumab
Proton Therapy