Phase I Study of Temozolomide, Valproic Acid and Radiation Therapy in Patients With Brain Metastases
Status:
Terminated
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
This type of study is called a "Phase I study". Its purpose is to determine the side effects
of the two medicines listed in this study when given together with whole brain radiation, and
the highest dose of valproic acid that can be given together with temozolomide and whole
brain radiation. We will also study the drug combination's effectiveness in treating cancer.
While both of these drugs and whole brain radiation have been used in people for many years,
they have never been combined for the purpose of treating patients with cancer.
Phase:
Phase 1
Details
Lead Sponsor:
H. Lee Moffitt Cancer Center and Research Institute