Phase II/III of Randomized Controlled Clinical Research on IRE Synchronous Chemotherapy for LAPC
Status:
Completed
Trial end date:
2021-07-30
Target enrollment:
Participant gender:
Summary
Previous studies have shown that irreversible electroporation (IRE) preoperative induction
chemotherapy or adjuvant chemotherapy after IRE can reduce the local recurrence rate of
locally advanced pancreatic cancer (LAPC) and benefit the survival of patients. According to
the technical principle of electroporation therapy (EPT), when the cell membrane is
electroporated, the resistance of cell membrane decreases instantaneously, which promotes the
drug to enter tumor cells and significantly increases its cytotoxicity and killing effect on
tumor tissue. The purpose of study is to evaluate the safety and effectiveness of
simultaneous gemcitabine administration and IRE for treating LAPC. In order to provide new
ideas for the treatment of LAPC.