RATIONALE: Successful allogeneic stem-cell transplantation is often limited by
graft-versus-host disease (GVHD). Migration of donor cells into tissues plays a major role in
GVHD. Drugs that block chemokine receptors such as CCR5, can potentially decrease the
migration of donor cells into tissues. Blocking CCR5 after allogeneic stem-cell
transplantation may therefore reduce the rates of GVHD.
PURPOSE: This study explores the efficacy of pharmacologic inhibition of CCR5 in prevention
of GVHDby administering maraviroc during allogeneic stem-cell transplantation with reduced
intensity conditioning.
Phase:
Phase 2
Details
Lead Sponsor:
Abramson Cancer Center of the University of Pennsylvania