Phase II Open-Label Pilot Study of V3381 in Chronic Cough
Status:
Terminated
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
The investigators hypothesise that cough reflex hypersensitivity, demonstrated in chronic
cough patients, is due to a phenomenon known as central sensitisation. Central sensitisation
is a hyper-excitability of the sensory nerves as they join the central nervous system, and is
believed to be mediated by the N-Methyl-D-Aspartate (NMDA) receptor[1-3].
Phase:
Phase 2
Details
Lead Sponsor:
Vernalis (R&D) Ltd
Collaborators:
Manchester University NHS Foundation Trust University Hospital of South Manchester NHS Foundation Trust