Phase II Pilot Study of Early Cortisol Replacement to Prevent Bronchopulmonary Dysplasia
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Estimate the efficacy of cortisol replacement therapy during the first 12 days
of life for prevention of bronchopulmonary dysplasia.
II. Estimate the effect of cortisol replacement therapy on the signs of acute adrenal
insufficiency.
III. Evaluate the effects of cortisol replacement therapy on adrenal hormone concentrations
and on the ability of the adrenal gland to respond to ACTH.
IV. Determine the effect of this replacement therapy on markers of inflammation in lung
lavage fluid and peripheral blood leukocytes.