Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis
Status:
Completed
Trial end date:
1999-09-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Compare the long term outcomes in patients with giant cell arteritis after
glucocorticoid treatment with or without methotrexate.
II. Compare remission relapse rates in these patients after glucocorticoid therapy with or
without methotrexate.
III. Determine whether adjunctive use of methotrexate lowers cumulative dose and duration of
glucocorticoid therapy and whether there is less treatment related morbidity and mortality.
IV. Demonstrate the feasibility of long term, double blind, placebo controlled, randomized,
multicenter trials for treatment of systemic vasculitides.