Phase II Study to Evaluate Safety and Efficacy of CB-103 With Venetoclax in Adolescent and Young Adult Patients With Relapsed/Refractory T-ALL or T-LBL

• Status: Not yet recruiting
• Trial end date: 2026-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To learn if the combination of 2 study drugs, CB-103 and venetoclax, can help to control T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic leukemia (T-LBL) in adolescent and young adult patients

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: M.D. Anderson Cancer Center
• Treatments: Venetoclax

Criteria

Inclusion Criteria:

• Adolescent (12 to 18 years), and young adult (19 to 40 years) patients who have relapse or refractory T-cell lymphoblastic leukemia (T-ALL) or T-Cell lymphoblastic lymphoma (T-LBL) according to 2017 WHO classification [29] and NCCN v1 2021 [30]:

• Patients must have ≥ 5% blasts in the bone marrow as assessed by morphology on standard bone marrow biopsy and aspirate or less than 5% blasts in the bone marrow in presence of extramedullary relapse, excluding isolated central nervous system (CNS) relapse. However, if an adequate bone marrow sample cannot be obtained, patients may be enrolled if there is unequivocal evidence of leukemia with ≥ 5% blasts in the peripheral blood.

• Patients are eligible independently of Notch pathway activation in the leukemic blasts:

However, a fresh marrow/blood sample must be obtained before starting the study treatment to classify the patients as being either Notch positive or negative.

• Leukemic blasts must express of at least 2 of the following immune phenotyping: CD1a, CD2, CD3, CD4, CD5, CD7, CD8, CD34, TCRαβ, TCRγδ, cyCD3

• Patients have adequate performance status (ECOG ≤2) for patients ≥16 years old, Lansky score >50 for patients <16 years old.

• Patients have a life expectancy of at least 4 months

• Patients must be 12 to 40 years of age inclusive when signing the informed consent. For patients < 18 years of age, parent or legally authorized representative (LAR) should be willing and able to give informed consent.

• Patients with asymptomatic CNS disease are eligible (see also Exclusion Criterion 3.2.4.)

• Patients must have adequate organ function and laboratory results (obtained within 14 days of enrollment):

• Direct bilirubin ≤2 x upper limit of normal (ULN).

• Serum creatinine ≤ 1.5 x ULN; or if serum creatinine > 1.5 x ULN, then serum creatinine clearance (CrCl) ≥ 50 mL/min (estimated by Cockcroft-Gault formula).

• Alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) ≤3 x ULN; ≤5 x ULN in case of suspected leukemic liver involvement

• Females of childbearing potential must have a negative serum or urine beta-human chorionic gonadotropin (β-HCG) pregnancy test result within 14 days prior to the first dose of study drugs and must agree to use one of the following effective contraception methods during the study and for 30 days following the last dose of study drug. Effective methods of birth control include:

• Birth control pills, skin patches, shots, implants (placed under the skin by a health care provider)

• Intrauterine devices (IUDs)

• Condom or occlusive cap (diaphragm or cervical/vault caps) used with Spermicide

• Abstinence

• Males agree to inform the doctor right away if the partner becomes pregnant or suspects pregnancy. While in this study and for 30 days after the last treatment the patient agrees not to donate sperm for the purposes of reproduction. He agrees to use a condom while in this study and for 30 days after the last treatment.

Exclusion Criteria:

• Patients who meet any of the following criteria will be excluded from participation in the study:

• Mixed phenotype leukemia (excluding T-ALL with myeloid antigen expression)

• History of another primary invasive malignancy that has not been definitively treated and in remission. Patients with non-melanoma skin cancers or with carcinomas in situ are eligible regardless of the time from diagnosis (including concomitant diagnoses).

• Presence of clinically significant uncontrolled CNS pathology such as epilepsy, childhood seizure, paresis, aphasia, stroke, severe brain injuries, organic brain syndrome, or psychosis.

• Evidence of active cerebral/meningeal disease. Patients may have history of CNS leukemic involvement if definitively treated with prior therapy and no evidence of active disease at the time of consent (see inclusion criterion 3.1.7.).

• Patients with a cardiac ejection fraction (as measured by either MUGA or echocardiogram) < 50% or with a history of absolute decrease in LVEF of ≥ 15 absolute percentage points are excluded.

• Medical history of cardiovascular disease such as:

• Clinically significant cardiac disease including congestive heart failure (NYHA class III or IV), arrhythmia or conduction abnormality requiring medication, or cardiomyopathy

• Clinically uncontrolled hypertension Age Blood Pressure 12 to 13 >120/80mmHg >13 >140/90mmHg

• Complete left bundle branch block

• Right bundle branch block + left anterior hemiblock

• Congenital long QT syndrome

• History or presence of sustained or symptomatic ventricular tachyarrhythmia, atrial fibrillation, or clinically significant resting bradycardia (< 50 bpm)

• Corrected QT interval using Fridericia formula (QTcF) > 450 ms for males and > 470 ms for females at the screening ECG

• QRS ≥ 110 ms

• History of symptomatic congestive heart failure

• Patients with uncontrolled, active infections (viral, bacterial, or fungal). Infections controlled on concurrent anti-microbial agents are acceptable, and anti-microbial prophylaxis per institutional guidelines are acceptable.

• Known active hepatitis B or C infection or known seropositivity for HIV.

• Liver cirrhosis or other active severe liver disease or with suspected active alcohol abuse.

• Have conditions requiring chronic systemic (not inhaled) glucocorticoid use, such as autoimmune disease or severe asthma. Low doses of corticosteroids (10 mg prednisone equivalent a day) are permitted.

• Patients with unresolved nausea, vomiting, or diarrhea of CTCAE version 5.0, grade ˃

1 from prior therapy.

• Patients with impairment of GI function or GI disease presence that significantly alter the absorption of CB-103 (e.g., ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection).

• Have current or recurrent (within 3 months) gastrointestinal disease, have conditions requiring chronic systemic glucocorticoid use, have active graft versus host disease, or have a second primary or prior malignancy that would affect the interpretation of study results.

• Prior chemotherapy/radiotherapy/investigational therapy within 2 weeks before the start of study drugs with the following exceptions:

• Up to 5 days of glucocorticoids (10 mg of dexamethasone or equivalent/day) in combination with up to 3 doses of cyclophosphamide (200 mg/m2

/day) are allowed as standard pre-phase treatment up to 1 day before start of study treatment. Cytarabine up to 2gm/m2 are also allowed as standard pre-phase treatment up to 1 day before start of study treatment.

• Mercaptopurine may be dosed up to 5 days prior to first dose of CB103

• Vinca alkaloids may be dosed up to 5 days prior to first dose of CB103

• Prophylactic intrathecal (IT) chemotherapy may be dosed up to 1 day prior to first dose of CB103

• Females who are pregnant or lactating.

• Male or female subjects of childbearing potential, unwilling to use an approved, effective means of contraception in accordance with institution's standards.

• Other severe, uncontrolled acute or chronic medical or psychiatric condition or laboratory abnormality that in the opinion of the Investigator may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and/or would make the patient inappropriate for enrollment into this study.

• Patients who are unable or unwilling to comply with all study requirements for clinical visits, examinations, tests, and procedures.

• Patients must be excluded if they are currently enrolled in another ongoing clinical trial with anti-cancer investigational products