Phase II Trial of Aprepitant & Palonosetron for CINV Prevention w FOLFOX

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Aprepitant, palonosetron, and dexamethasone may help lessen or prevent nausea and vomiting in patients receiving chemotherapy.

PURPOSE: This phase II trial is studying how well giving aprepitant together with palonosetron and dexamethasone works in preventing nausea and vomiting caused by chemotherapy in patients receiving chemotherapy for metastatic colorectal cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: OHSU Knight Cancer Institute
• Collaborator: National Cancer Institute (NCI)
• Treatments: Aprepitant; BB 1101; Camptothecin; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Fluorouracil; Fosaprepitant; Irinotecan; Leucovorin; Levoleucovorin; Oxaliplatin; Palonosetron

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of colorectal cancer

• Metastatic disease

• Scheduled to receive 1 of the following chemotherapy regimens*:

• FOLFOX 4 (oxaliplatin, fluorouracil, leucovorin calcium)

• FOLFOX 6

• FOLFOX 7

• FOLFIRI (irinotecan hydrochloride, fluorouracil, leucovorin calcium) NOTE:

*Regimens may also include cetuximab or bevacizumab

• No emesis and no requirement for antiemetic agents within 48 hours prior to beginning chemotherapy

• Single-agent benzodiazepines as a hypnotic allowed

• No chronic nausea

PATIENT CHARACTERISTICS:

• Eastern Cooperative Oncology Group (ECOG) performance status 0-2

• Life expectancy > 4 months

• White Blood Cell(WBC)count > 3,000/mm^³

• Absolute neutrophil count (ANC) > 1,500/mm^³

• Platelet count > 100,000/mm^³

• Bilirubin ≤ 2.5 times upper limit of normal (ULN) (< 5 times ULN if liver metastases present)

• Creatinine ≤ 1.5 times ULN

• Aspartate aminotransferase(AST) or Alanine aminotransferase (ALT) ≤ 2.5 times ULN (< 5 times ULN if liver metastases present)

• Able to swallow tablets and capsules

• No known sensitivity to aprepitant, palonosetron hydrochloride, or dexamethasone

• Not pregnant or nursing

• Negative pregnancy test

• No history of consuming ≥ 5 alcoholic drinks/day within the past year

• No concurrent illness requiring systemic corticosteroids other than planned dexamethasone during study treatment

• No clinical signs of active systemic infection involving the gastrointestinal tract

• No active bowel obstruction

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• No prior chemotherapy > Hesketh level 3

• Prior fluorouracil with or without leucovorin calcium or capecitabine allowed

• At least 30 days since prior investigational drugs

• At least 14 days since prior neurokinin-1 antagonists

• Concurrent hydrocortisone at physiologic replacement doses (≤ 30 mg/day) allowed

• No concurrent chronic antiemetic agents

• Concurrent hypnotics allowed

• Concurrent rescue antiemetics allowed