Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
A randomized Phase II trial to test whether the addition of intraoperative Photofrin-mediated
photodynamic therapy to radical pleurectomy and post-operative chemo.improves OS in the
treatment of patients with epithelioid MPM. Subjects assigned to the PDT arm will be given
the photosensitizer prior to surgery . All subjects will receive maximal surgical debulking.
Subjects in the PDT arm will receive intraoperative treatment using real-time, isotropic
light dosimetry.
Phase:
Phase 2
Details
Lead Sponsor:
Abramson Cancer Center of the University of Pennsylvania