Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
Status:
Recruiting
Trial end date:
2026-06-25
Target enrollment:
Participant gender:
Summary
The study is intended to show superiority of AZD9833 in combination with CDK4/6 inhibitor
(palbociclib or abemaciclib) versus aromatase inhibitors (anastrozole or letrozole) in
combination with CDK4/6 inhibitor in patients with hormone receptor-positive (HR-positive),
human epidermal growth factor receptor 2-negative (HER2-negative) metastatic breast cancer
with detectable ESR1 mutation