Overview
Phenethyl Isothiocyanate in Preventing Lung Cancer in People Who Smoke
Status:
Completed
Completed
Trial end date:
1969-12-31
1969-12-31
Target enrollment:
0
0
Participant gender:
All
All
Summary
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Phenethyl isothiocyanate may be effective in preventing lung cancer in smokers. PURPOSE: Phase I trial of phenethyl isothiocyanate in preventing lung cancer in people who smoke.Phase:
Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
New York University School of Medicine
NYU Langone HealthCollaborator:
National Cancer Institute (NCI)Treatments:
Phenethyl isothiocyanate
Criteria
DISEASE CHARACTERISTICS: Asymptomatic smokers who either refuse to or cannot stop smokingUrinary cotinine levels greater than 100 ng/mL Willing to adhere to certain dietary
restrictions limiting intake of cruciferous vegetables (watercress, broccoli, radishes,
mustard, brussels sprouts) while on study
PATIENT CHARACTERISTICS: Age: Not specified Performance status: Not specified Life
expectancy: Not specified Hematopoietic: WBC at least 3,500/mm3 Platelet count at least
100,000/mm3 Hepatic: Bilirubin less than 1.6 mg/dL Transaminases less than 2 times normal
Renal: Creatinine less than 1.6 mg/dL Urinary RBC levels 0-2 Urinary WBC levels at least
0-2 Pulmonary: No dyspnea at rest Other: No concurrent illness, condition, or symptom that
would preclude study Not pregnant or nursing Negative pregnancy test Fertile patients must
use effective contraception
PRIOR CONCURRENT THERAPY: Not specified