Overview Phenylalanine and Its Impact on Cognition Status: Recruiting Trial end date: 2022-08-01 Target enrollment: Participant gender: Summary The PICO-Study is a randomized, placebo-controlled, crossover, non-inferiority trial conducted to add evidence to the current European treatment guidelines for adult patients with phenylketonuria. Phase: Phase 4 Details Lead Sponsor: University Hospital Inselspital, BerneCollaborator: University of Zurich