Phenylephrine Versus Ephedrine in Pre-eclampsia

• Status: Terminated
• Trial end date: 2016-07-08
• Target enrollment: 0
• Participant gender: Female

Summary

Phenylephrine administration is associated with reductions in CO and SctO2 compared with ephedrine when used for blood pressure management in women with pre-eclampsia undergoing cesarean delivery under spinal anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Ephedrine; Oxymetazoline; Phenylephrine; Pseudoephedrine

Criteria

Inclusion Criteria:

• English speaking

• Age ≥18 yrs

• Pre-eclampsia (mild, or severe)

• Non-laboring women

• CD under spinal anesthesia

Exclusion Criteria:

• Height < 5'0"

• Allergy to phenylephrine or ephedrine, or any other standardized medication

• Severe Cardiac disease in pregnancy with marked functional limitations (NYHA Class III and IV)

• Patients on Monoamine Oxidase Inhibitors or Tricyclic Antidepressants

• History of recent amphetamine or cocaine use.

• Subject enrollment in another study involving a study medication within 30 days of CD

• Any other physical or psychiatric condition which may impair their ability to cooperate with study data collection