Phenylephrine Versus Norepinephrine for Maintenance of Hemodynamic During Cesarean Section Under Spinal Anesthesia

• Status: Completed
• Trial end date: 2020-12-02
• Target enrollment: 0
• Participant gender: Female

Summary

Comparison between prophylactic continuous variable infusion of phenylephrine (starting dose 0,5mcg/kg/min) and norepinephrine tartrate (starting dose 0,1mcg/kg/min) to prevent hypotension and maintain cardiac output under spinal anesthesia during cesarean delivery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Régional d'Orléans
• Treatments: Anesthetics; Bupivacaine; Morphine; Norepinephrine; Oxymetazoline; Phenylephrine; Sufentanil

Criteria

Inclusion Criteria:

• Pregnancy higher than 36 weeks of amenorrhea

• Scheduled or semi-urgent (interval between decision and delivery by cesarean section higher than 12hours) cesarean section under spinal anesthesia

Exclusion Criteria:

• Extreme height (less than 140cm; higher than 180cm)

• Weight less than 50kg

• Weight higher than 120kg

• Cardiovascular disease with use of cardiac medication (including antihypertensive drug)

• Active neurological disease

• Anti-hypertension treatment.

• High blood pressure or severe pre-eclampsia

• American Society of Anesthesiologists physical status class higher than 3

• Placenta accrete/percreta

• Cesarean section scheduled under general anesthesia

• Contraindications to spinal anesthesia

• Minor (age less than 18 years old)

• Guardianship/ curatorship

• Anemia less than or equal to 8 g/dl

• Allergy to any study medication

• Simultaneous participation in another study