Overview Phenylketonuria, Oxidative Stress, and BH4 Status: Terminated Trial end date: 2013-06-01 Target enrollment: Participant gender: Summary The purpose of this study is to see how tetrahydrobiopterin therapy (BH4; also known as sapropterin dihydrochloride or Kuvan) affects measures of oxidative stress and endothelial function in patients with Phenylketonuria (PKU). Phase: Phase 2 Details Lead Sponsor: Emory UniversityTreatments: Verapamil