The proposed research is a randomized-controlled trial to determine the effectiveness of
reducing serum phosphorus using a phosphate binder, lanthanum carbonate, for improving the
function of arteries in adults with moderate to severe chronic kidney disease (CKD). [COMIRB
13-0328] Additionally, it will determine phosphorus balance among adults with CKD and whether
there is a difference in phosphorus balance after three months of treatment with lanthanum
carbonate. [COMIRB 15-0384]