Physiologic Investigation of the Renin Angiotensin Aldosterone Axis in HIV
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to see if individuals with HIV-infection, particularly those
with increased belly fat, have abnormalities in the renin angiotensin aldosterone axis.
Renin, angiotensin, and aldosterone are hormones that regulate salt and water balance in the
body, and they may also have effects on sugar metabolism and cardiovascular health. There is
some evidence that individuals with HIV-associated abdominal fat accumulation may have
increased aldosterone, which may contribute to abnormalities in sugar metabolism and
increased cardiovascular disease seen in HIV. The purpose of this study is the measure renin,
angiotensin, and aldosterone activity, as well as other hormonal axes, in people with and
without HIV infection, and with and without increased belly fat. The investigators
hypothesize that aldosterone will be increased in HIV-infected individuals compared to those
without HIV-infection, and that aldosterone will be further increased in HIV-infected
individuals with increased abdominal fat compared to those without abdominal fat
accumulation.