Physiopathology of Sodium Retention in Acromegaly

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Acromegaly is a disease due to an excess of growth hormone that abnormally occurs in adulthood. It is due to a benign (non cancerous) tumor located in a particular part of the brain that secretes several hormones, the hypophysis. The excess of growth hormones in adults induces an increase in bone (resulting in large enlargement of extremities), and organs. The disease is complicated by the apparition of cardiovascular events including retention of water, salt in the tissues and increase in blood pressure, that altogether might major the mortality of the patients. The investigators recently got experimental data suggesting that the retention of water and salt is mainly due to the activation by the growth hormone of a renal transporter of sodium. Because this transporter is highly sensitive to amiloride, a well know diuretic, the investigators hypothesize that this drug will be very efficient in treating the hypertension in patients, as compared to another diuretic, furosemide.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborator: Institut National de la Santé Et de la Recherche Médicale, France
• Treatments: Furosemide

Criteria

Inclusion Criteria:

• age 18 to 75 yrs

• proven evolutive acromegalia with indication of treatment (surgical or medical)

• controlled blood pressure (systolic BP < 140 mmHg et diastolic BP < 90 mmHg)

• signed informed consent

• efficient contraception in women

Exclusion Criteria:

• edematous state unrelated to acromegaly

• history of sulfamide intolerance

• hemoglobin < 8g/dL

• pregnant or breastfeeding women

• inability to give informed consent

• blood donation in the preceding 3 months