Overview
Pilocarpine in Treating Vaginal Dryness in Patients With Breast Cancer
Status:
Completed
Completed
Trial end date:
2012-12-01
2012-12-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
RATIONALE: Pilocarpine may decrease vaginal dryness and improve quality of life in patients with breast cancer It is not yet known whether pilocarpine is more effective than a placebo in treating vaginal dryness in patients with breast cancer. PURPOSE: This randomized phase III trial is studying pilocarpine to see how well it works compared to a placebo in treating vaginal dryness in patients with breast cancer.Phase:
Phase 3Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Alliance for Clinical Trials in OncologyCollaborator:
National Cancer Institute (NCI)Treatments:
Pilocarpine
Criteria
Required Characteristics:1. Adult post menopausal women or women with no childbearing potential (≥ 18 years) with
a history of breast cancer (currently no evidence of disease) or women who do not want
to take vaginal estrogen for a fear of an increased risk of breast cancer.
Postmenopausal status will be determined by the primary physician.
2. Significant vaginal complaints defined as persistent vaginal dryness and/or itching of
sufficient severity to make a patient desire therapeutic intervention. Symptoms should
have been present ≥ 2 months prior to randomization.
3. Life expectancy > 6 months
4. Ability to complete questionnaire(s) by themselves or with assistance.
Contraindications:
1. Initiation or discontinuation of tamoxifen or aromatase inhibitors ≤2 months prior to
randomization or plans to initiate or discontinue any of these medications during the
6-week study.
2. Active vaginal infection
3. Concurrent chemotherapy
4. Acute iritis
5. Current or past use of pilocarpine (regardless of purpose)
6. Planned use of any vaginal preparations during the study period (including any over
the counter or herbal preparations). Note: Lubricants used during sexual intercourse
are permitted.
7. Use of any vaginal preparations ≤ 1 week prior to study entry (Exception: If patient
has used vaginal preparations during the previous week but will stop, then they can be
placed on study with plans to start with pretreatment questionnaire one week later).
Note: Lubricants used during sexual intercourse are permitted.
8. Current (≤ 4weeks prior to randomization), or planned during the study period, use of
any estrogen product.
9. A diagnosis of asthma, COPD, CAD or narrow angle glaucoma, or known cholelithiasis.
10. Hepatic or renal insufficiency defined as a history of an elevation of SGOT ≥1.5 x ULN
or creatinine ≥ 1.5 x ULN within the past year.
11. Concurrent use of other anticholinergics
12. Use of pharmacologic soy preparations
13. Known history of cardiac arrhythmia. (Patients with occasional PVC's or PAC's that do
not require treatment are eligible.)
14. Prior or concurrent pelvic radiation therapy
15. Prior radical pelvic surgery (TAH/BSO is allowed)
16. Use of beta adrenergic antagonists
17. Diagnosis of any of the following conditions:
- Vulvar and vaginal dysplasia
- Essential vulvodynia
- Vulvar vestibulitis
- Vaginal prolapse
- Bartholin cyst/abscess
- History of Bartholin gland surgery
- Lichen sclerosis
- Lichen planus of the vulvovaginal region
- Desquamative vaginitis