Pilot Biomarker Trial to Evaluate the Efficacy of Itraconazole in Patients w/ Basal Cell Carcinomas
Status:
Completed
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
Basal cell carcinomas (BCCs) are the most common human cancer in the US and affect over 1
million people. There is no effective drug to prevent basal cell carcinomas of the skin.
We hope to learn if an oral anti-fungal drug, itraconazole, might inhibit a marker of
proliferation and a biomarker (tumor signaling pathway) of BCC development.
Itraconazole is an FDA-approved drug for the treatment of fungal infections of the skin, and
has been used for the past 25 years with relatively few side effects. It has been shown in
mice to reduce a BCC biomarker and to reduce growth of BCCs.
Thus, it may reduce BCC growth in humans.