Pilot Study About Safety and Efficacy of Atomized Intrapleural Lidocaine During Pleuroscopy

• Status: Withdrawn
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the potential to decrease the use of IV anesthesia drugs in patients undergoing pleuroscopy administering lidocane standardly applied to the skin in combination with atomized lidocaine applied into the pleural cavity.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lahey Clinic
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Patients diagnosed with pleural disease

• Patients undergoing pleuroscopy with talc with or w/o biopsy

• Patients aged 18 - 85

• Patients capable of signing informed consent

Exclusion Criteria:

• Severe congestive heart failure

• Hepatic failure, bilirubin > 2mg/dl, ALT,AST 3XULN

• Prior use Lidocaine in 48 hrs

• Hx SA drug reaction to lidocaine or amide local anesthetics

• Second or third degree heart block (w/o pacemaker)

• Sever sinoatrial block (w/o pacemaker)

• Concurrent treatment with quinidine, flecainide, dsopyramide, procainamide (ClassI antirrhythmic agents)

• Prior use or amiodarone hydrochloride

• systolic BP < 90mmHg

• bradycardia

• accelerated idioventricular rhythm