Overview
Pilot Study: Hepatoprotective Role of SMOFlipid® Used in Short-term Parenteral Nutrition in an Onco-Hematology Pediatric Population
Status:
Completed
Completed
Trial end date:
2016-10-01
2016-10-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Parenteral nutrition (PN) is part of supportive care in oncology Pediatric when the patient's nutritional status justifies it and enteral is impossible. In the literature, hepatotoxicity, cholestasis type, standard emulsions of soy oil-based (type Médialipide®) is described in the context of a long-term PN especially in premature infants. It results in an increase in gammaGT. The most recent use of lipid emulsions containing Omega 3 (Smoflipid), was studied in the adult population and in the preterm in the PN on short and long, with the finding of a hepatoprotection. Investigators do not find a single retrospective study about it in Pediatric Onco-Hematology. No prospective studies have been performed in the population of Onco-Hematology. The objective of this study is to evaluate the impact of the use of SMOFlipid® in parenteral nutrition on early occurrence of cholestasis compared with Médialipides in a short-term use of parenteral nutrition in an Onco-Hematology pediatric population.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Centre Hospitalier Universitaire de NiceTreatments:
SMOFlipid
Criteria
Inclusion Criteria:- 0-18 years
- Solid Tumors
- hematological malignancies
- Requiring parenteral nutrition during at least 5 days
- With a central catheter
- With a normal hepatic function test
Exclusion Criteria:
- Liver function tests disrupted
- Patient with a tumor or liver metastases
- Patient with against-indication to the use of lipid